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recheck TSH at 6 wk | | Oral contraceptives (EE/LNG) | Gastric emptying delay | Cmax reduced ~13 to 20% | Moderate | Switch to non-oral contraception or add barrier method | | Digoxin | Gastric emptying delay | Cmax reduced ~15 to 25%

The impact of BMI on treatment response is well illustrated by the AQUILA study, which examined real-world outcomes in PsA patients treated with (65).In this cohort, obese individuals exhibited higher circulating levels of IL-17, supporting the concept that IL-17driven inflammation may be particularly prominent in this subgroup and may contribute to increased disease activity and reduced therapeutic responsiveness (66)

A study compared the effects of Saxenda and Wegovy on weight loss, and patients who used Wegovy lost 15.85% of their weight, while the Saxenda group lost 6.4% of their body weight

But the fuel available for recovery has dropped by a third or more