Finally, another report proposed the synthesis of PLGA nanocarriers decorated with PEG and glutathione (GSH), for the intracellular delivery of curcumin: the double functionalization resulted in an increased NP uptake by neuronal cells and, in particular, the GSH conjugation modified the NP internalization pathway, avoiding the lysosomal degradation and increasing the therapeutic fate for potential application in the treatment of AD (Paka and Ramassamy, 2017)
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2 After 12 months, the treatment group had significantly greater reductions in RA disease activity, pain scores, and several markers of cardiovascular risk, including total cholesterol and HbA1c (a measure of average blood sugar levels)
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