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Based on commercially available analogues a preliminary structureactivity relationship study revealed that substitution of the amino position (R1, R2) showed broad tolerability of aliphatic groups and that lipophilic substituents of the phenyl group at the 3 position (R3) in the ortho and meta positions were well tolerated

Statistical analyses were run in Statistica v.8 and R v.3.0.2 (35)

Glutathione has a significant role in detoxifying dietary ethanol (alcoholic beverages), and anyone who drinks regularly will deplete their glutathione levels (6)