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The Gap Between Animal Promise and Clinical Evidence The disconnect between BPC-157's strong animal hepatoprotective data and the absence of human liver-specific trials represents one of the widest evidence gaps in peptide therapeutics

Annals of Hepatology vol

In vivo evidence corroborates this finding, such that mice with an ApoE4 background display an over 10x higher HSV-1 load in the brain compared to mice with an ApoE3 background, strikingly with viral DNA also being detected in the ovaries, spinal cord and trigeminal ganglia in infected ApoE4 mice (Flowers and Rebeck, 2020), thus offering less overall antimicrobial protection, but also mechanistically as ApoE4 prevents HSV-1 cellular attachment but crucially not viral entry or replication, and can also be incorporated into the HSV-1 virion that can enhance release from the cell (Feng et al., 2023), which would be an issue for viral AD

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