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Nat Rev Neurosci 12:524538
diabetes-focused comparison Semaglutide, dulaglutide (higher doses), and tirzepatide all routinely drop A1C by around 1 % to 2 %, with tirzepatide again edging out the rest at the top end of that range
Treatment with L-Carnitine (300 mg/kg) and alpha-lipoic acid (100 mg/kg) for 28-30 days in aged rats restores activities of succinate dehydrogenase, malate dehydrogenase, -ketoglutarate dehydrogenase, isocitrate dehydrogenase, and respiratory complexes I-IV to near-normal levels, indicating enhanced mitochondrial energy-producing capacity
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