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Both are introductory doses, but they belong to different medications and cannot be directly compared in strength

Early signs include reduced appetite, smaller portion sizes, decreased food cravings, less interest in high-calorie snacks, and what many describe as quieter "food noise." These appetite and behavioral changes typically precede visible weight loss by several weeks

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In mediation analysis, semaglutide was found to have a direct effect on reducing total daily insulin dose by 8.9 U per day to 11.4 U per day, with the largest effect observed at the start of treatment