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Phase 2 clinical trials for retatrutide used a gradual titration protocol, starting at 2 mg and increasing every four weeks up to the target dose

[12] [13] In August 2008, four additional deaths from pancreatitis in users of exenatide were reported to the FDA

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J Biol Chem 280:1182911839 Johnston WA, Stewart M, Lee P, Cooney MJ (2003) Tracking the acetate threshold using DO-transient control during medium and high cell density cultivation of recombinant Escherichia coli in complex media