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Conclusions/interpretation A dose-dependent superiority on glycaemic efficacy and body weight reduction was evident with tirzepatide vs placebo, GLP-1 RAs and basal insulin
Some users experience nausea, indigestion, bloating, or stomach discomfort, particularly when taking pills on an empty stomach
doi: 10.3390/ijms17091534 201 ZuoY
Secondly, we implemented several design features to mitigate biases: we defined a causal framework, used direct acyclic graphs to guide the selection of confounders, specified new user, active comparator target trials, and used inverse probability weighting to adjust for a comprehensive set of covariates from multiple data domains
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