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Patients with previous pancreatitis, gallstones, hypertriglyceridaemia, or excessive alcohol use face higher risk and require careful assessment before treatment

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Practical comfort measures: Wear lightweight, breathable clothing on injection days Keep sleeping environment cooler than usual for the 2448 hours post-injection Stay well hydrated increased metabolic activity raises fluid needs Avoid alcohol around injection time it can amplify flushing If the Warmth Is Disruptive Consider injection timing: If warmth and flushing peak at 1224 hours post-injection, injecting on a day when disruption matters less (e.g., Friday evening if you don't work weekends) may help manage impact on daily life