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Among those who switched, more than 8 out of 10 (82.8%) patients switched to AOM semaglutide
This trend represents a serious public health concern, as obesity is linked to increased mortality and is a major risk factor for health conditions including cardiovascular disease and type II diabetes
Therefore, some benefits on clinical and metabolic features of PCOS may not have fully emerged from the current studies, suggesting the need for additional RCTs, to expand the evidence on high-dose liraglutide effects
Tirzepatide in SYNERGY-NASH achieved ~50 to 60 %, Semaglutide in ESSENCE ~40 %
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