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A recent randomized and double-blind trial revealed that, for adults with poorly controlled T2DM, oral semaglutide at total doses of 25 mg and 50 mg was more effective than the 14-mg total dose in reducing HbA1c and body weight (33)
Hence, it was being prescribed off label for weight loss (as the diabetic drug, Ozempic) long before it was FDA approved as Wegovy for obesity
In these cases, carnitine becomes the drug of choice, capable of alleviating the effects of such dysmetabolic states
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