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doi: 10.3389/fendo.2022.846903 Received 31 December 2021 Accepted 01 February 2022 Published 21 February 2022 Volume 13 - 2022 Edited by Paolo Moghetti, University of Verona, Italy Reviewed by Flavia Prodam, University of Eastern Piedmont, Italy Updates Copyright 2022 Cignarelli, Genchi, Le Grazie, Caruso, Marrano, Biondi, DOria, Sorice, Natalicchio, Perrini, Laviola and Giorgino
Key Takeaway: GHK-Cu acts through multiple overlapping mechanisms fibroblast activation, controlled copper delivery, antioxidant signaling, and broad gene-expression modulation
Additionally, the appetite-suppressing effects of these medications often lead to reduced food and fluid intake, which can further contribute to constipation if adequate fibre and fluids aren't maintained
Layer one the inflammation-insulin loop
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