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Another meta-analysis of the same seven trials similarly reported that GLP-1RAs significantly reduced MACE, with a number needed to treat (NNT) to prevent one MACE of 73 (95% CI 45212) ( Reasons that have been postulated to account for the lack of positive effect in the ELIXA trial are the different trial populations (such that biological processes after an acute coronary event may be less amenable to modification than those relating to general atherosclerosis) and the short duration of action of lixisenatide (insufficient GLP-1 receptor stimulation over the 24-hour dosing period) ( What Is the Place of GLP-1RAS in the Guidelines for Patients With Diabetes and Cardiovascular Disease
Side Effects of Semaglutide Common Side Effects Most side effects are related to the digestive system and may improve over time: Nausea Vomiting Diarrhea Constipation Abdominal pain Decreased appetite These are often more noticeable when starting treatment or increasing the dose
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Even when performed by the best, any surgery is taxing on the body and triggers a widespread stress response in the body
