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The proposed mechanism most often cited involves GIP-receptor-mediated effects on adipose insulin sensitivity and possibly on central energy balance, though attribution between the two receptors in vivo remains an area of ongoing study

Mammalian target of rapamycin complex 1 suppresses lipolysis, stimulates lipogenesis, and promotes fat storage

This is the change your patients describe when they tell you, "my skin is just different now" or "my hair won't grow back the way it used to." The second story is less well-known

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