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Only medullary thyroid carcinoma and MEN2 syndrome prevent GLP-1 use
This critical difference means it functions as a targeted lipolytic agent rather than a systemic hormone, allowing for fat metabolism enhancement without the appetite disruptions, cortisol elevation, or blood sugar effects associated with growth hormone therapy
In one published case, an active, lean-adjacent man lost about one-third of his total weight as muscle on 2.5 mg and recovered it after adding resistance training and increasing protein. This is a cautionary case, not an incidence estimate
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