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In June 2022 the UK medicines regulator updated its advice: the MHRA now lists low vitamin B12 as a common side effect of metformin, meaning it can affect up to one in ten people taking it
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(Provides pharmacological details on pyridoxine, including its role as a coenzyme in neurotransmitter synthesis and interactions such as the antagonism of levodopa and reduction of phenytoin levels)
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