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A safety review in the Journal of Obesity & Food Metabolism describes six randomized, double-blind, placebo-controlled trials evaluating AOD-9604, including oral dosing studies and longer phase II programs

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Summarizing the obtained results, sulindac cytotoxic activity against COLO 829 melanotic melanoma cells, comparable to the reference drug, dacarbazine, is related to the induction of oxidative stress in cancer cells and the stimulation of the apoptosis process

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