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BMC Endocrine Disorders, 23 (1), 89
Weight loss continues through 72-88 weeks in clinical trials, so premature discontinuation prevents accurate assessment of treatment response
Cardiolipin can be oxidized by ROS or by the cardiolipincytochrome c complex ( c from cardiolipin might also be triggered by increased cytosolic calcium, which weakens the electrostatic interaction between cytochrome c and cardiolipin and further generates ROS via MPT
For pharmaceuticals, however, Congress created a partial offset through the Drug Price Competition and Patent Term Restoration Act of 1984 commonly called the Hatch-Waxman Act which allows patent holders to apply for patent term extensions (PTEs) of up to five years to compensate for time lost during FDA review, subject to a cap of 14 years of post-approval protection [3]
