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Concurrently, mechanistic insights from Wangs team have elucidated that the cellular uptake of large or highly polar beyond-Rule-of-5 (bRo5) molecules is mediated by CD36-dependent endothelial cell uptake, leading to the proposal of a chemical endothelial cell drug chemistry (CEMC) strategy [269]

Specifically, GL-0001 represents a first-in-class dual-acting GIP/GLP-2 peptide that improves bone biomechanical properties, preserves trabecular bone structure as well as increasing collagen cross-linking

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doi:10.1016/j.freeradbiomed.2006.01.036