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It is unique because it can pass through the mitochondria and enter the nucleus of the cell, where it activates signals that promote normal metabolic homeostasis of glucose and lipid metabolism
A reason for this behaviour could be that H 2 O 2 does not oxidize GSH directly, but rather through the action of glutathione peroxidase 26
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Besides, in response to cellular stress Clic4 translocates to the nucleus for the control of apoptotic processes [42] making it another pivotal protein of the tianma-activated signalling cascade
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