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This is not a failure of willpower but rather a predictable biological response to the removal of pharmacological intervention

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J Biol Chem (2008) 283(13):872335.10.1074/jbc.M706105200 45 WinklerDGSutherlandMKGeogheganJCYuCHayesTSkonierJEet alOsteocyte control of bone formation via sclerostin, a novel BMP antagonist