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Data Sources, Study Search, and Inclusion and Exclusion Criteria A thorough literature search was performed using three bibliographic databases, Cochrane, Embase, and PubMed, from inception to May 2024

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With ROXY9 showing no measurable reductase activity towards low molecular weight substrates HED, Cys-SG or CHP, our focus shifted to roGFP2 as a potential protein substrate