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FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice
This pulsatile pattern is considered more physiologically appropriate than continuous GH elevation, and is preserved across multiple administration cycles
SASP is characterized by the release of inflammatory and tissue-degrading molecules that can impair tissue function and structure, potentially leading to age-related deterioration
Furthermore, Biotin (vitamin B7) and ACUPA (urea-based substrate analog inhibitor of PSMA) have also been explored by different studies for modification of nanoparticles to achieve specific cell targeting [249, 250]
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