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Upon food ingestion and its subsequent entry into the small intestine, intestinal L-cells undergo posttranslational processing of the proglucagon gene, leading to the production of glucagon-like peptide-1 (GLP-1), a potent incretin peptide hormone 9

Post-hoc analysis of the SURMOUNT trial data found that tirzepatide relative to placebo was not associated with increased risk of depressive symptoms

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