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Oral Side Effects (Rare): In some sensitive individuals, very high doses of oral supplements may lead to mild side effects such as: Bloating or gas Abdominal cramps Allergic reactions (e.g., rash) in people sensitive to sulfur compounds
Many pharmaceutical companies offer contract manufacturing services, but specific capabilities, certifications, and processes vary by company
Epidemiologic studies have demonstrated that at least 6% of filled prescriptions for either acetaminophen alone or acetaminophen in combination with opioids exceeded 4000 mg per day of acetaminophen, which is a cause for real concern
Some specialized short term regimen call for daily dosing under experienced supervision
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