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The authors of one trial (95) included in the above-mentioned meta-analysis (89) noted that little cognitive decline was observed in the placebo group over their two-year trial, which may have limited their power to detect an effect of the B-vitamin intervention (95)
In rare cases, particularly with severe megaloblastic anaemia, rapid correction of B12 deficiency can affect potassium distribution in the body
Moreover, vegetarians and vegans who may not consume enough B12-rich foods are at a higher risk of developing a deficiency
No high-quality evidence supports the safety or benefit of this stack in humans
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