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Retatrutide remains investigational and is not FDA-approved as of May 2026
The researchers also found an increased risk of developing "other optic nerve disorders"

Contrave highlights of prescribing information, Food and Drug Administration (2024) Wegovy highlights of prescribing information, Food and Drug Administration (2024) Effect of naltrexone plus bupropion on weight loss in overweight and obese adults (COR-I): A multicentre, randomised, double-blind, placebo-controlled, phase 3 trial, The Lancet (2010) Weight regain and cardiometabolic effects after withdrawal of semaglutide: The STEP 1 trial extension, Diabetes, Obesity and Metabolism (2022) Label: Contrave extended-release naltrexone hydrochloride and bupropion hydrochloride tablet, extended release, DailyMed (2024) Label: Wegovy- semaglutide injection, solution, DailyMed (2024) Update on FDAs ongoing evaluation of reports of suicidal thoughts or actions in patients taking a certain type of medicines approved for Type 2 diabetes and obesity, Food and Drug Administration (2024) Medically accurate: SingleCares Medical Review Board analyzes all of our content to confirm its in line with current medical advice
