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Published in Biochemical Pharmacology and by researchers at University of Texas Medical Branch
The peptides mechanism NNMT inhibition to increase NAD+ availability is physiologically sound, but sustained enzyme suppression over months or years has not been studied in clinical trials
A B12 overdose might trigger nausea or diarrhea
A randomized, placebo-controlled trial in 559 elderly individuals with low serum levels of folate and vitamin B 12 and at increased risk of fracture evaluated the combined supplementation of very high doses of folic acid (5 mg/day) and vitamin B 12 (1.5 mg/day)
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