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Metabolic conditions during fasting sleep states (low insulin, elevated free fatty acids from overnight lipolysis, reduced glucose) optimize growth hormone secretion
In June 2025, the European Medicines Agency officially recognized NAION as a very rare side effect of semaglutide after reviewing all data, concluding it may affect up to 1 in 10,000 people and recommending product information updates
The frequency of headaches appears to vary by dose in some studies, though this relationship hasn't been systematically evaluated specifically for headache as an adverse effect
however, semaglutide has been shown in head-to-head studies to provide more weight loss than Liraglutide
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