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Sensitivity analyses were performed to assess the impact of the definition of MACE (three-point MACE [non-fatal myocardial infarction, non-fatal stroke and cardiovascular death] vs other MACE definitions), risk of bias, data source (electronic healthcare records vs other data sources) and method of adjusting for confounding (propensity scores or inverse probability of treatment weighting vs multivariable regression, restriction or matching)

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doi: 10.1016/j.fertnstert.2008.02.097 40 ValentPBettelheimP

These mechanisms address insulin resistance more directly than traditional treatments such as metformin, which primarily reduces glucose production in the liver