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Lifestyle interventions were the least effective treatment, the investigators found, producing a mean total body weight loss of 7.4% at the end of the treatment period, followed by a mean per-month weight regain of 0.14%, with participants reaching their pre-intervention weights within 4.1 years

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These results do not apply to compounded versions of GLP-1 drugs, which are not FDA-approved and have not been evaluated for safety, effectiveness, or quality