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In two recent studies, knock-in mice carrying dominant-negative Nr1h3 mutations (W441F and W441R) exhibited more severe liver injury than Nr1h3 -knockout mice following a MASH-inducing diet 32,52

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In human somatic cells, telomerase is normally silenced after embryonic development, meaning telomeres shorten with each cell division until reaching a critical length that triggers replicative senescence or apoptosis