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Data acquisition Exendin-4: Data for the GLP1R:DNGs:exendin- complex was collected on a Titan Krios microscope operated at 300 kV (ThermoFisher Scientific equipped with a Gatan Quantum energy filter operating in Zero Loss mode with an energy slit with of 20 eV and a Gatan K2 Summit direct electron detector (Gatan)

FIGURE 2 3.5 SPAE attenuates genotoxicity induced by DEX Dexamethasone (DEX) administration caused marked genotoxic damage in liver cells, as assessed by comet assay parameters, including tail length, tail DNA percentage, and tail moment