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Patients should focus on: Protein-rich foods at each meal (lean meats, fish, eggs, legumes, dairy) to support satiety and preserve lean muscle mass during weight loss High-fibre vegetables and whole grains to promote fullness and support digestive health Adequate hydration (1.52 litres daily for most people, though those with heart or kidney conditions should follow clinician advice on fluid intake) to distinguish thirst from hunger and support metabolic processes Mindful eating practices , including eating slowly, recognising fullness cues, and avoiding distractions during meals Limiting ultra-processed foods , which are typically energy-dense but nutrient-poor and may not trigger appropriate satiety signals Avoiding heavy alcohol consumption , particularly given the increased risk of pancreatitis with GLP-1 receptor agonists Physical activity plays a crucial role in weight management and metabolic health

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Future research should further define their role in comprehensive hypertension management

In Phase 2 trials (the TRIUMPH-2 study involving 338 participants over 48 weeks), the 12 mg dose of Retatrutide produced an average weight loss of 24.2%