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826 Repressor element 1-silencing transcription factor (REST) is the main regulator of gene inhibition under hypoxia, and its expression level is positively correlated with the degree of kidney injury

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In two studies examining the 6-month effects of semaglutide, patients with metabolic dysfunction-associated steatotic liver diseases (MASLD) and showed reduced skeletal muscle steatosis with preservation of muscle mass [86], whereas in patients with MASLD and human immunodeficiency virus, semaglutide led to a 9.3% decrease in psoas muscle volume with no change in muscle fat fraction [87]

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