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Phosphorylation of Ser-129 is the dominant pathological modification of -synuclein in familial and sporadic Lewy body disease

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Brit J Clin Pharmacol

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Common hypothyroidism symptoms can include: Fatigue and lethargy Brain fog and memory issues Constipation Dry skin Thinning hair or loss of the outer portion of eyebrows Unexplained weight gain Joint pain or stiffness Mood swings and depression Sensitivity to cold temperatures Irregular menstrual cycles Infertility What Causes Hypothyroidism

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Several and unrelated mechanisms are responsible for drug resistance to cisplatin

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