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Methods Comparative network pharmacology effectiveness analysis of DM2 DMTs in preventing AD comorbidity in DM2 Reconstruction of the DM2-AD pathway-pathway comorbidity network To assess the therapeutic potential of DM2 DMTs in preventing comorbid AD in DM2, we first reconstructed the DM2-AD pathway-pathway comorbidity network, following an established methodology from previous work 19

Venous blood samples were stored at 20 C in polypropylene tubes until analysed, 80 L of ethylenediaminetetraacetic acid (EDTA) plasma was used to assess cagrilintide pharmacokinetics at each timepoint, thus 16 mL EDTA plasma from each participant was used

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