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While Ipamorelin is generally well-tolerated with minimal adverse effects reported, Tesamorelin may cause injection site reactions, transient increases in blood sugar levels, and potentially exacerbate pre-existing conditions such as diabetes

Berberine may interact with antidiabetic medications, anticoagulants, and drugs metabolised by CYP450 enzymes

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23 Therefore, we first aimed to improve and optimize the approach for functional gene screen by replacing the EFS promoter 21 with the CAG promoter in the DKO-AG-haESC line carrying an Oct4-EGFP transgene (Supplementary information, Fig