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But, a recent study suggests another mechanism may be at work: taste

Additionally, we adopted another study design, the Mendelian randomization (MR) analysis, to provide more reliable insights into causal associations of GLP-1 RAs with different severity of DR [19, 20]

Trials such as the STEP 2 and SURMOUNT 3 programs have consistently shown average weight loss of ~1520% of baseline body weight compared to placebo over long-term treatment periods