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These drugs are metabolized primarily through proteolytic degradation by peptidases throughout the body, not through hepatic cytochrome P450 enzymes or biliary excretion pathways
O.SonawaneB.2009The influence of genetic polymorphisms on population variability in six xenobiotic-metabolizing enzymes.125-6, (2009),307333,1093-7404 37
Moreover, skeletal investigations indicate that localized growth plate responses can occur independently of significant systemic endocrine shifts [4]
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