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However, we did not observe these effects in the present study, despite administering doses that are comparable to those used in clinical trials

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The patient has established cardiovascular disease with a documented history of at least one of the following: A) Previous myocardial infarction (MI) B) Previous stroke C) Symptomatic peripheral arterial disease (PAD), evidenced by one of the following: Intermittent claudication with an ankle-brachial index (ABI) less than 0.85 at rest Peripheral arterial revascularization procedure Amputation due to atherosclerotic disease D) Prior revascularization, such as coronary artery bypass grafting (CABG), percutaneous coronary intervention (PCI), or angioplasty, and

Poly(ADP-ribose) polymerase-deficient mice are protected from streptozotocin-induced diabetes