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To address this challenge, we sought to develop long-acting formulations of semaglutide and liraglutide providing continuous therapy for upwards of four months from a single administration to coincide with the typical cadence with which T2D patients visit their endocrinologist or primary care provider (Figure 1B and C) ( 27 )

doi: 10.3389/fgene.2016.00095

Systolic (SBP) and diastolic blood pressure (DBP) were also consistently reduced by incretin-based drugs, ranging from 3.1 and 0.57 mmHg with liraglutide 3.0 mg to 9.2 and 5.1 mmHg with retatrutide, respectively

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