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Larger-scale federally licensed compounders (503B outsourcing facilities) have until March 19, 2025, to wind down their production and distribution of compounded tirzepatide

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Chiral HPLC or Marfey analysis may be warranted to confirm correct D-Trp and D-Phe stereochemistry, as racemization during synthesis can produce less active or inactive diastereomers

Both follow a similar four-week titration schedule