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Ethics approval and consent to participate This study was reviewed by the Natural and Non-prescription Health Products Directorate (NNHPD), Health Canada and a research ethics board, which granted ethics approval in December, 2014
Achieving these stringent endpoints, as outlined in the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE-II) consensus ( Research into mucosal healing has highlighted pathways involving interleukin-20 (IL-20), claudin-2 (CLDN2), and notoginsenoside R1 (NGR1) ( Figure 1 illustrates the differences in immune cell distribution within the intestinal crypts under homeostatic conditions compared with the inflammatory microenvironments of CD and UC
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