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Vitamin B12 can interact with medications such as colchicine (a medicine used to treat gout), metformin (an anti-diabetic agent), excessive alcohol, vitamin C products, extended release potassium products, antibiotics such as gentamicin, neomycin, tobramycin, anti-seizure medications such as phenobarbital, phenytoin, primidone, medicines used to treat heartburn like H2 blockers such as cimetidine and proton pump inhibitors such as omeprazole, antacids such as ranitidine, cimetidine

The four combination compounds were chosen due to their widespread usage

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Creatine for the brain: how higher doses may enhance cognition under stress and support resilience against aging and disease [A: 1:16:30, V: 1:23:26]